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Northwestern has dropped 28 of its last 29 games against Ohio State.
So what if that were to change this weekend?
"It'd be huge for us," Wildcats quarterback Trevor Siemian said.
Siemian joined ESPN.com's "Kickoff Live" on Thursday for a video interview previewing Saturday's big game in Evanston, when the No. 16 Cats host No. 4 Ohio State.
"They're a really good team, got a lot of talent," Siemian continued. "There's a reason they're the No. 3 or 4 team in the country, and we certainly respect them. We feel like we've got a pretty good team, too. So we're excited to play them and hopefully win on Saturday."
The potential importance of this weekend's high-profile game is certainly in the minds of the Wildcats. A win could be a big step for the program, and Siemian knows it could bring the Cats closer to achieving their goals.
"I think (our goals are) competing for Big Ten championships and going to Rose Bowls year in and year out," he said. "I think we're right on the cusp of that, and games like this one coming up Saturday help mold that perception and the direction of this team and program, where it's going."
Siemian is part of coach Pat Fitzgerald's two-quarterback system, along with Kain Colter. And when asked what makes the system work so well, Siemian echoed his coach, saying it's not the system but the two guys themselves.
"We've got a great relationship," he said of Colter and himself. "We're really good friends, so I think that certainly helps being able to communicate effectively and at the same time put our egos to the side. Especially playing quarterback, I feel like that would get in the way in a lot of cases. But we've got a great relationship, we're good buddies. And I'm not scared to give him a hard time, and he certainly gives me a hard time. So I think that helps. It's whatever helps the team, so that's where we're going with it."
Siemian also touched on the hype and media attention surrounding the game, as well as the return of running back Venric Mark. Click the link above to see the entire interview.