Jose Abreu is the latest member of the White Sox to hit the disabled list.
The first baseman, who leads the majors with 15 home runs and is second with 42 RBIs, was placed on the 15-day DL with posterior tibia tendonitis in his left ankle, the team announced Sunday.
The White Sox activated leadoff man Adam Eaton from the DL on Sunday.
Abreu has paced a resurgent White Sox offense that is second in the American League with 217 runs scored. Behind Abreu's record-setting April, in which he established records for homers and RBIs before May 1 by a rookie, the White Sox are averaging 4.93 runs per game on the heels of one of the worst offensive campaigns in franchise history. In 2013, the club scored fewer than 600 runs for the first time in a full season since 1980. That group finished near the bottom of the majors in almost every offensive category.
With Abreu, who has a .260/.312/.595 slash line in 189 plate appearances, the White Sox are in the top three in runs, hits, doubles, homers and average. The club also has seen its on-base percentage rise to .325 after it finished last season at .302.
Abreu has played with a sore ankle since spring training, though it has gotten worse in the past 10 days. Even though he was playing in pain that manager Robin Ventura has said makes him wince, Abreu has insisted all along he could play through the ankle pain. As recently as Wednesday, Abreu said he didn't want to rest on Friday that Thursday's off-day would be plenty of time for the ankle to rest and he would return to the lineup for the team's series opener against the Houston Astros.
But the pain in Abreu's ankle was enough that Ventura pulled him for a pinch hitter in the seventh inning of Saturday's game in Houston. Afterward, Abreu told reporters in Houston his ankle felt worse and conceded he would probably sit Sunday's game.
The loss is yet another in a long line of big blows for the White Sox this season.
Already the offense is without outfielder Avisail Garcia, who suffered a season-ending torn labrum last month. Eaton, their catalyst at the top, has been on the DL for the past 15 days with a right hamstring strain.
Third baseman Conor Gillaspie, who is hitting .333 with 15 RBIs, missed 15 days with a sore left hand and second baseman Gordon Beckham also started the season on the DL with a left oblique strain.
The White Sox also have been without starting pitcher Chris Sale since April 17 with a sore left flexor muscle. Fellow starter Felipe Paulino went on the DL shortly after Sale and reliever Nate Jones has been out since April 4 with a sore lower back.
In Abreu's absence the White Sox are likely to play both Paul Konerko and Adam Dunn on a full-time basis.